Aegean Airlines have announced a new flight from Manchester to Athens. You will now be able to book a “connection through” flight from Manchester to Mytilene.
Flights are two days a week (Saturday and Monday). With only two flights a week these are going to fill quickly so I would suggest you book well in advance to get the best prices.
Aegean has regular special offers so join their mailing list to get early info on discounts.
Aegean Airlines Website
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I would like to be informed of lowest prices between Manchester and Mytiline for summer 2017
The Aegean summer 2017 schedule has not been released yet. It should be available soon.
You can check for the lowest prices at https://en.aegeanair.com/plan/low-fare-calendar/